A Series of Lectures of "SINANO Nanobiomedicine Top Talks"

纳米生物医学高端访谈

系列学术讲座

A Series Lectures of "Nanobiomedicine Top Talks” 

 Topic 1:

Human Stem Cell Research and Regenerative Medicine　

 Lecturer:

Prof. Miodrag Stojkovic, the Editor of STEM CELLS

 Abstract:

Stem cells are cells with the ability to grow and differentiate into more than 200 cell types. The differentiation ability of all stem cell types could be stimulated to obtain specialized cells that represent renewable sources of functional cells useful for cell-based therapy. The proof of functional differentiated cells needs to be investigated in more detail using both in vitro and in vivo assays including animal disease models and clinical studies. Much progress has been made in the adult stem cell-based therapies. Meanwhile human embryonic stem cells and induced pluripotent stem cells have dramatically emerged as novel approaches to understand pathogenesis of different diseases. These and a number of new strategies become very important in regenerative medicine. Therefore, there is a need to discuss i) latest development, ii) the perspectives and iii) the limitations of stem cells.

 Topic 2:

 Lecturer:

 Abstract:

My group’s research is focused on three key stem cell areas, namely: (i) understanding of self renewal in human pluripotent stem cells; (ii) generation of functional and transplantable blood cells from human pluripotent stem cells and (iii) clinical translations of our basic biology studies to treat corneal and retinal blindness. In today’s talk I will concentrate on key issues that we face with respect to development of defined transplantable cell types for clinical applications from human pluripotent stem cells. Over the last 5 years we have been able to establish a very efficient model of human ESC differentiation to haematopoietic lineages and retinal photoreceptors cells. Using this differentiation model, we have established a transcriptional network which we are using to understand the role of key transcription factors and miRNAs that govern directed differentiation. Using this molecular signature, we can discuss how similar these cells are to the ones that are found in equivalent niches in the adult. One of the most fascinating aspects of stem cell development in the last four years has been induction of pluripotency in differentiated cells. My group in collaboration with Dr Lyle’s Armstrong’s group has now established more than 100 iPSC lines using various integrative and non integrative methods. I will discuss how we are using these patient specific cells to understand disease development in early embryos.

 TIME:

9:30am - 11:30m, September 14 (Wednesday)

 LOCATION:

Room A718, SINANO