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Repurposing Blu-ray Technology: From High-resolution Imaging to Molecular Diagnostics

Update time:Dec 15, 2016

Speaker:Prof.YU Huazhong,Department of Chemistry, Simon Fraser University, Vancouver, Canada

Sponsor:Prof.PEI Renjun

Time: 4:30p.m.Monday,December 19th

Place:A415,SINANO

Abstract:

Current guidelines for healthcare emphasize rapid testing and reporting, which can be better satisfied by point-of-care (POC) diagnostic tools rather than centralized medical laboratories using automated multi-analyte analyzers by trained professionals. With POC testing, the turn-around time can be significantly reduced, leading to earlier decision making and more efficient medical treatment. At present, POC protocols are predominantly based on rapid-test immunoassay strips/cassettes that combine gold nanoparticles for colorimetric (mostly qualitative) detection and flow-through systems for sample delivery. Optical disc technology provides a promising alternative to today’s POC testing protocol; we have established both the surface chemistry and signal reading methodology for running bioassays of various molecular analytes on bona fide Blu-ray discs; these bioDiscs can be read quantitatively with standard computer drives or stand-alone disc players, i.e., without any modifications to the hardware and software driver.

1.Yu, H.-Z.; Li, Y.; Ou, L.M.L. Acc. Chem. Res. 2013, 46, 258-268.

2.Li, X.; Weng, S.; Ge, B.; Yao, Z.; Yu, H.-Z. Lab Chip. 2014, 14, 1686–1694.

3.Weng, S.; Li, X.; Niu, M.; Ge, B.; Yu, Yu, H.-Z. Anal. Chem. 2016, 88, 6889–6896


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