1.Lipid nanoparticle for high efficiency RNA delivery
2. RNA-based cell reprogramming for organoid preparation
3.Gene therapy for ocular diseases
Employment
2022 - Professor Nanobiomedicine Division, SINANO, CAS
2016 - 2021 Postdoctoral Research Associate/Research Assistant Professor, UNC Chapel Hill
2015 - 2016 Research Associate UT El Paso
Education
Ph.D. 2014 Polymer and Fiber Engineering Auburn University
B.S. 2010 Materials Engineering Soochow University
1. Kai Wang, Min Zheng, Charles Askew, Xintao Zhang, Chengwen Li, Ashutosh Chikoti, and Zongchao Han, Elastin-like polypeptide facilitated adeno-associated virus transduction with pre-existing immune response, Advanced Therapeutics, doi: 10.1002/adtp.202200128
2. Kai Wang, Sarah Ahn, Yuhui Chen, Min Zheng, Elisa Landoni, Gianpietro Dotti, Barbara Savoldo, and Zongchao Han GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision, Nature Cancer, 2020, 1, 990–997.
3. Kai Wang, Min Zheng, Zongchao Han, Light-induced Nrf2-/- mice as atrophic age-related macular degeneration model and treatment with nanoceria laden injectable hydrogel, Scientific Reports, 2019, 9, 14573
4. Ruijuan Gao, Rajendra Narayan Mitra, Min Zheng, Kai Wang, Jesse Dahringer, Zongchao Han Developing nanoceria-based pH-dependent cancer-directed drug delivery system for retinoblastoma, Advanced Functional Materials, 2018, 1806248
5. Kai Wang, Rajendra Narayan Mitra, Min Zheng, Zongchao Han. Nanoceria-loaded injectable hydrogels for potential age-related macular degeneration treatment, Journal of Biomedical Materials Research Part A, 2018, 106, 2795-2804
6. Kai Wang, Zongchao Han. Injectable hydrogels for ophthalmic application, Journal of Controlled Release, 2017 268, 214-224
7. Mitra, Rajendra N., Ruijuan Gao, Min Zheng, Ming-Jing Wu, Maxim A. Voinov, Alex I. Smirnov, Tatyana I. Smirnova, Kai Wang, Sai Chavala, and Zongchao Han. Glycol Chitosan Engineered Auto-Regenerative Antioxidant Significantly Attenuates Pathological Damages in Models of Age-Related Macular Degeneration, ACS Nano 2017 11 (5), 4669–4685
8. Kai Wang, Krishna C. Nune and Devesh K. Misra. The functional response of alginate-gelatin-nanocrystalline cellulose injectable hydrogels toward delivery of cells and bioactive molecules, Acta Biomaterialia, 2016, 36, 143-151
