1. Peptide based novel therapeutics development;
2. Cytotoxicity mechanisms of chemical & nanomaterials;
3. Functional probes for biosensing and bioimaging;
Employment
2008 - Assoc. Prof.- Professor Nanobiomedicine Division, SINANO, CAS
2005 - 2008 Assistant Researcher UCLA, Los Angeles, CA
2001 - 2004 Postdoc. Research Fellow Vollum Institute, OHSU, Portland, OR
Education
Ph.D. 2001 Biochemistry and Molecular Biology SIBCB, CAS
B.S. 1996 Biochemistry Nanjing University
1.Liu X, Cao R, Wang S, Jia J, Fei H*. Amphipathicity determines different cytotoxic mechanisms of lysine- or arginine-rich cationic hydrophobic peptides in cancer cells. J. Med. Chem. 2016 May 19;
2.Wang Q, Ma X, Jia J, Fei H*. A peptide–lipid nanoparticle assembly platform with integrated functions for targeted cell delivery. J. Mater. Chem. B, 2016, 4, 1535 - 1543
3.Ma X, Jia J, Cao R, Wang X, Fei H*. Histidine–iridium(III) coordination-based peptide luminogenic cyclization and cyclo-RGD peptides for cancer-cell targeting. J. Am. Chem. Soc. 2014, 136 (51): 17734-17737.
4.Ma X, Wang X, Zhou M, Fei H*. A Mitochondria-Targeting Gold-Peptide Nanoassembly for Enhanced Cancer-Cell Killing. Adv Healthc Mater. 2013. Dec; 2(12):1638-43.
5.Cao R, Jia J, Ma X, Zhou M, Fei H*. Membrane localized iridium(III) complex induces endoplasmic reticulum stress and mitochondria-mediated apoptosis in human cancer cells. J. Med. Chem. 2013 May 9;56(9):3636-44.
6.Wang X, Jia J, Huang Z, Zhou M, Fei H*. Luminescent Peptide Labeling based on a Histidine-binding Iridium(III) Complex for Cell Penetration and Intracellular Targeting Studies. Chemistry – A European Journal. 2011 Jul 11;17(29): 8028-32.
7.Fei H, Karnezis T, Reimer RJ, Krantz DE: Membrane topology of Drosophila vesicular glutamate transporter. J. Neurochem. 2007 Jun;101(6):1662-71.
8.Scott GK, Fei H, Thomas L, Megideshi G, Thomas G: PACS-1, GGA3 and CK2 cooperate to control CI-MPR trafficking. EMBO J. 2006 Oct 4;25(19):4423-35.
9.Fei H, Luo MJ, Ye YZ, Ding DF, Chi CW: The Inhibitory Activities of Recombinant Eglin C Mutants on Kexin and Furin, Using Site-directed Mutagenesis and Molecular Modeling. Acta Biochimica et Biophysica Sinica. 2001;33(6):591-599.
